Experimental design and control methods for dose rate optimization in a synchrotron‐based proton therapy beamline
Tungsten scatterer thickness modulation provides a practical, controllable method for dose rate adjustment spanning conventional to FLASH regimes. This passive approach enables precise dose rate control for preclinical radiobiological research without requiring modifications of accelerator structure and parameters.
Authors
- Daniel Liu (ORCID: https://orcid.org/0000-0002-4153-504X)
- Paige A. Taylor (ORCID: https://orcid.org/0000-0001-9720-8059)
- Sabrina N. Campelo (ORCID: https://orcid.org/0000-0001-6570-7427)
- Lawrence F. Bronk (ORCID: https://orcid.org/0000-0001-6798-1788)
- Jason Tang (ORCID: https://orcid.org/0000-0002-7456-6256)
- Fada Guan (ORCID: https://orcid.org/0000-0001-8477-7391)
- Yuting Li (ORCID: https://orcid.org/0000-0003-3372-9722)
- Jacob Mathew (ORCID: https://orcid.org/0000-0001-8013-1163)
Institutions
- The University of Texas MD Anderson Cancer Center (US)
- Yale University (US)
- University of Houston (US)
- The University of Texas at Austin (US)
Publication Details
- Journal
- Precision Radiation Oncology
- Published
- 2025-11-29
- DOI
- https://doi.org/10.1002/pro6.70032
- Primary Topic
- Radiation Therapy and Dosimetry
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Cancer Prevention and Research Institute of Texas
- University of Texas MD Anderson Cancer Center
- National Cancer Institute