Positioning uncertainties in single-target longitudinal segmentation for hippocampal-avoidance whole brain radiotherapy using volumetric modulated arc therapy

Hippocampal avoidance whole-brain radiotherapy (HA-WBRT) aims to preserve cognitive function during treatment for brain metastases. This study investigated the potential of Single-Target Longitudinal Segmentation Volumetric Modulated Arc Therapy (VMAT) in HA-WBRT, which segments the planning target volume (PTV) into sub-PTVs, using single or dual arcs to generate s-VMAT and d-VMAT strategies. For 20 patients, s-VMAT and d-VMAT achieved lower median Dmean values of 8.3 Gy and 8.1 Gy, and reduced the median Dmax to 13.5 Gy and 12.8 Gy, compared to traditional coplanar/non-coplanar VMAT plans. These strategies showed enhanced robustness but required more monitor units and greater delivery complexity.

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Publication Details

Journal
Physics and Imaging in Radiation Oncology
Published
2025-10-01
DOI
https://doi.org/10.1016/j.phro.2025.100862
Primary Topic
Advanced Radiotherapy Techniques
Type
article
Field-Weighted Citation Impact
0.00

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article

Positioning uncertainties in single-target longitudinal segmentation for hippocampal-avoidance whole brain radiotherapy using volumetric modulated arc therapy

Minfeng Huang, Jun Yuan, Chunbo Tang, Biaoshui Liu et al.
Physics and Imaging in Radiation Oncology
Advanced Radiotherapy Techniques
article

Positioning uncertainties in single-target longitudinal segmentation for hippocampal-avoidance whole brain radiotherapy using volumetric modulated arc therapy

Minfeng Huang, Jun Yuan, Chunbo Tang, Biaoshui Liu, Houjin Zhang, Junjie Zhang, Pengfei Wang, Ji He, Longqiu Wu
article en

Abstract

Hippocampal avoidance whole-brain radiotherapy (HA-WBRT) aims to preserve cognitive function during treatment for brain metastases. This study investigated the potential of Single-Target Longitudinal Segmentation Volumetric Modulated Arc Therapy (VMAT) in HA-WBRT, which segments the planning target volume (PTV) into sub-PTVs, using single or dual arcs to generate s-VMAT and d-VMAT strategies. For 20 patients, s-VMAT and d-VMAT achieved lower median Dmean values of 8.3 Gy and 8.1 Gy, and reduced the median Dmax to 13.5 Gy and 12.8 Gy, compared to traditional coplanar/non-coplanar VMAT plans. These strategies showed enhanced robustness but required more monitor units and greater delivery complexity.

Physics and Imaging in Radiation OncologyVol. 36
Sun Yat-sen University (CN), Xian Central Hospital (CN), Second Affiliated Hospital of Guangzhou Medical University (CN), Jiangxi Provincial Cancer Hospital (CN), Gannan Medical University (CN), First Affiliated Hospital of Gannan Medical University (CN), Sun Yat-sen University Cancer Center (CN), Shaoxing People's Hospital (CN), Guangzhou Medical University (CN)
National Natural Science Foundation of China
Openalex Percentile: Top 54%
Advanced Radiotherapy Techniques
DOIOpen Access PDFOpenAlex
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Positioning uncertainties in single-target longitudinal segmentation for hippocampal-avoidance whole brain radiotherapy using volumetric modulated arc therapy — Minfeng Huang, Jun Yuan, et al. · Physics and Imaging in Radiation Oncology (2025) | TGRS Research Map | TGRS