Proton pump inhibitors are associated with increased risk of pseudoarthrosis after lumbar fusion
Postoperative PPI use is associated with a significantly increased risk of pseudoarthrosis following lumbar spine fusion. These findings suggest careful consideration of the necessity of PPI therapy in the perioperative period, particularly in younger patients where the relative impact appears the greatest.
Authors
- Emily Mills (ORCID: https://orcid.org/0000-0001-5527-5464)
- Sohaib Hashmi (ORCID: https://orcid.org/0000-0003-4228-1421)
- Abhinav K. Sharma (ORCID: https://orcid.org/0000-0003-4932-6629)
- Vivian Y. Chen (ORCID: https://orcid.org/0000-0002-8038-9719)
- Don Young Park (ORCID: https://orcid.org/0000-0003-3575-2758)
- Andy Ton (ORCID: https://orcid.org/0000-0002-8891-0353)
- Hao‐Hua Wu (ORCID: https://orcid.org/0000-0003-1048-3889)
- Nitin Bhatia (ORCID: https://orcid.org/0000-0001-7905-3305)
- Ryan Le (ORCID: https://orcid.org/0000-0003-2695-2053)
- Yu-Po Lee (ORCID: https://orcid.org/0000-0002-2365-2373)
- Michael Kim (ORCID: https://orcid.org/0000-0002-2532-5851)
- Melissa Romoff
- Courtney Spitzer (ORCID: https://orcid.org/0000-0002-1646-3275)
Institutions
- University of California, Irvine (US)
- University of California, Irvine Medical Center (US)
Publication Details
- Journal
- North American Spine Society Journal (NASSJ)
- Published
- 2025-11-29
- DOI
- https://doi.org/10.1016/j.xnsj.2025.100829
- Primary Topic
- Spine and Intervertebral Disc Pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00