Nattokinase supplementation for cognitive enhancement in asymptomatic intracranial/carotid stenosis: A randomized controlled trial
Six-month NK supplementation did not improve global cognition in asymptomatic intracranial/carotid stenosis patients. However, domain-specific enhancement in visuospatial function suggests potential selective neuroprotective effects.
Authors
- Xuting Zhang (ORCID: https://orcid.org/0000-0002-1522-4694)
- Wansi Zhong (ORCID: https://orcid.org/0000-0002-4775-7778)
- Min Lou (ORCID: https://orcid.org/0000-0002-6627-064X)
- Kemeng Zhang (ORCID: https://orcid.org/0000-0001-9093-5632)
- Shuyue Wang (ORCID: https://orcid.org/0000-0002-6099-4452)
- Yingjian Pei (ORCID: https://orcid.org/0009-0008-0648-0013)
- Cong Chen (ORCID: https://orcid.org/0000-0003-0875-7473)
- Haidi Jin (ORCID: https://orcid.org/0009-0001-5658-3087)
- Anni Wang (ORCID: https://orcid.org/0000-0002-3793-8196)
- Ziyu Zhou (ORCID: https://orcid.org/0009-0003-6587-3056)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking Union Medical College Hospital (CN)
- Second Affiliated Hospital of Zhejiang University (CN)
- Fu Wai Hospital (CN)
Publication Details
- Journal
- Journal of Stroke and Cerebrovascular Diseases
- Published
- 2025-11-29
- DOI
- https://doi.org/10.1016/j.jstrokecerebrovasdis.2025.108511
- Citations
- 1
- Primary Topic
- Cerebrovascular and Carotid Artery Diseases
- Type
- article
- Field-Weighted Citation Impact
- 1.52
Funders
- National Natural Science Foundation of China
- National Health Commission of the People's Republic of China