Early senescence in salivary glands: A multimodal analysis across parotid, submandibular, and sublingual glands
By middle age, salivary glands exhibit early senescent changes, senescent cell accumulation, altered proliferative capacity, and shifts in Jmjd3-mediated epigenetic regulation, which occur in parallel with histological changes.
Authors
- Kiyomi Ogawa
- Tetsuro Horie (ORCID: https://orcid.org/0000-0002-6713-6725)
- Kenichiro Kikuchi (ORCID: https://orcid.org/0009-0003-8903-7896)
- Koichi Shibagaki
Institutions
- Nippon Dental University (JP)
Publication Details
- Journal
- Journal of Oral Biosciences
- Published
- 2025-11-29
- DOI
- https://doi.org/10.1016/j.job.2025.100717
- Primary Topic
- Salivary Gland Disorders and Functions
- Type
- article
- Field-Weighted Citation Impact
- 0.00