Histidine-rich glycoprotein ameliorated lung ischemia-reperfusion injury in a mouse model
HRG supplementation ameliorated lung IRI in mice by suppressing inflammatory responses triggered by neutrophil-associated factors, including formation of NETs, HMGB1 translocation, and accumulation of hemolytic products.
Authors
- Kazuhiko Shien (ORCID: https://orcid.org/0000-0002-4959-4220)
- Mikio Okazaki (ORCID: https://orcid.org/0000-0002-7202-244X)
- Akihiro Matsukawa (ORCID: https://orcid.org/0000-0002-5081-6089)
- Shinichi Toyooka (ORCID: https://orcid.org/0000-0002-7588-6745)
- Ken Suzawa (ORCID: https://orcid.org/0000-0003-2463-9696)
- Toshio Shiotani (ORCID: https://orcid.org/0000-0003-1218-2908)
- Daiki Ousaka (ORCID: https://orcid.org/0000-0002-8577-9062)
- Shin Tanaka (ORCID: https://orcid.org/0000-0002-0014-9230)
- Toshiaki Ohara (ORCID: https://orcid.org/0000-0003-1557-1589)
- Seiichiro Sugimoto (ORCID: https://orcid.org/0000-0001-6649-4777)
- Dengli Wang (ORCID: https://orcid.org/0000-0002-0380-494X)
- Yujiro Kubo (ORCID: https://orcid.org/0000-0001-7083-7066)
- Yasuyuki Hosono
- Kentaroh Miyoshi (ORCID: https://orcid.org/0000-0003-1589-1216)
Institutions
- Okayama University of Science (JP)
- Okayama University (JP)
- Okayama University Hospital (JP)
- Hospital Universitario Puerta de Hierro Majadahonda (ES)
Publication Details
- Journal
- JHLT Open
- Published
- 2025-11-29
- DOI
- https://doi.org/10.1016/j.jhlto.2025.100453
- Primary Topic
- Advanced Glycation End Products research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Japan Society for the Promotion of Science