Late‐onset unexplained epilepsy as a risk factor for cognitive impairment and dementia: Protocol for a multi‐center prospective longitudinal observational study ( <scp>ELUCID</scp> )
The ELUCID study is a research project involving several medical centers across the U.S. It will focus on older adults who have recently developed seizures without a clear cause. Participants undergo an initial evaluation that includes questions about their medical history, a brain MRI, an overnight scalp EEG (brain wave study), and a blood draw. They will be followed over time with health questionnaires and yearly tests of memory and thinking. The purpose of the study is to learn what factors increase the risk of dementia in this population and to develop tools to predict which individuals are at the highest risk.
Authors
- Leah J. Blank (ORCID: https://orcid.org/0000-0001-8719-6752)
- Emily L. Johnson (ORCID: https://orcid.org/0000-0001-6457-938X)
- Lori B. Chibnik (ORCID: https://orcid.org/0000-0001-6293-806X)
- Rodrigo Zepeda (ORCID: https://orcid.org/0000-0001-6551-1723)
- Mouhsin M. Shafi (ORCID: https://orcid.org/0000-0002-4531-1967)
- Michael Brandon Westover (ORCID: https://orcid.org/0000-0003-4803-312X)
- Rani A. Sarkis (ORCID: https://orcid.org/0000-0001-8291-7864)
- Gad A. Marshall (ORCID: https://orcid.org/0000-0002-9096-2355)
- Tyler E. Gaston (ORCID: https://orcid.org/0000-0002-6525-789X)
- Douglas N. Greve (ORCID: https://orcid.org/0000-0002-0610-0155)
- Nathalie Jetté (ORCID: https://orcid.org/0000-0003-1351-5866)
- Kyle R. Pellerin (ORCID: https://orcid.org/0009-0000-4856-7602)
- Alice Lam (ORCID: https://orcid.org/0000-0001-7754-4637)
- Rebecca England Amariglio (ORCID: https://orcid.org/0009-0009-5878-8930)
Institutions
- Brigham and Women's Hospital (US)
- Beth Israel Deaconess Medical Center (US)
- Harvard University (US)
- Johns Hopkins University (US)
- University of Calgary (CA)
- Johns Hopkins Medicine (US)
- University of Alabama at Birmingham (US)
- Massachusetts General Hospital (US)
- Athinoula A. Martinos Center for Biomedical Imaging (US)
- The University of Texas Southwestern Medical Center (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Epilepsia Open
- Published
- 2025-11-29
- DOI
- https://doi.org/10.1002/epi4.70184
- Citations
- 1
- Primary Topic
- Epilepsy research and treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.47
Funders
- National Institutes of Health