Towards Clinical Translation: Establishing Optimal Dose and Dose-Rate Parameters for the FLASH Skin-Sparing Effect
In this study, a dual-threshold framework was established to guide the clinical implementation of FLASH radiotherapy: a dose ceiling below 24 Gy to preserve the skin-sparing effect and a dose-rate threshold exceeding 200 Gy/s for efficacy, with further optimization achieved at rates above 250 Gy/s. These findings provide guidelines for minimizing radiotherapy-induced acute skin toxicity while maintaining comparable antitumor efficacy, thereby outlining a translatable pathway towards the clinical translation of FLASH-RT.
Authors
- Jinyi Lang (ORCID: https://orcid.org/0000-0002-5406-8671)
- Jie Zhou (ORCID: https://orcid.org/0000-0002-6002-291X)
- Xiaohua Chen (ORCID: https://orcid.org/0000-0002-5722-705X)
- Siyu Xie (ORCID: https://orcid.org/0000-0001-7234-7861)
- Chenxi Yang (ORCID: https://orcid.org/0000-0003-3219-704X)
- Shuo Wang (ORCID: https://orcid.org/0000-0001-5095-1435)
- Yongjie Li (ORCID: https://orcid.org/0000-0002-7395-3131)
- Shun Lu (ORCID: https://orcid.org/0000-0002-1833-475X)
- Lintao Li (ORCID: https://orcid.org/0000-0002-1837-8664)
- Yiyuan Shen (ORCID: https://orcid.org/0009-0000-5954-270X)
- Wei Tang (ORCID: https://orcid.org/0000-0003-3356-0226)
Institutions
- Macau University of Science and Technology (MO)
- University of Electronic Science and Technology of China (CN)
Publication Details
- Journal
- Dose-Response
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1177/15593258251401947
- Primary Topic
- Radiation Therapy and Dosimetry
- Type
- article
- Field-Weighted Citation Impact
- 0.00