Fine‐Scale Mapping of HLA‐C Haplotype Structural Diversity Using SNP Crossover Regions Flanked by Transposable Element Markers in Homozygous Cell Lines

HLA-C haplotypes exhibit modular mosaic structures shaped by recurrent recombination at TE-associated crossover zones. Thus, MHC haplotypes may share the same HLA-C allele, yet differ in the surrounding HLA-B and class I genomic organization, preserving or disrupting co-adapted functional units. Incorporating haplotypic mosaicism, rather than focusing solely on allelic polymorphism, may improve models of immune variation, disease risk, and translation matching.