Dual-target mechanisms of olanzapine in bipolar disorder: a network pharmacology and molecular docking study revealing phase-specific regulation of longevity and PI3K-Akt pathways

Authors

Kai Jiang (ORCID: https://orcid.org/0009-0001-6712-3342)
Xiangdong Du (ORCID: https://orcid.org/0000-0002-9263-0178)
Jun Zhang (ORCID: https://orcid.org/0000-0002-5002-9827)
Hongliang Zhu
Ronghua Li (ORCID: https://orcid.org/0000-0002-8282-3232)
Tingting Jin (ORCID: https://orcid.org/0000-0002-5896-7092)
Guangya Zhang (ORCID: https://orcid.org/0009-0009-3544-9805)
Xuna Yang
Dan Wang (ORCID: https://orcid.org/0000-0001-7281-4853)

Institutions

Suzhou Guangji Hospital (CN)

Publication Details

Journal: BMC Psychiatry
Published: 2025-11-29
DOI: https://doi.org/10.1186/s12888-025-07661-y
Primary Topic: Bipolar Disorder and Treatment
Type: article
Field-Weighted Citation Impact: 0.00

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article

Dual-target mechanisms of olanzapine in bipolar disorder: a network pharmacology and molecular docking study revealing phase-specific regulation of longevity and PI3K-Akt pathways

Kai Jiang, Xiangdong Du, Jun Zhang, Hongliang Zhu et al.

Nov 29, 2025

BMC Psychiatry

Bipolar Disorder and Treatment

article

Dual-target mechanisms of olanzapine in bipolar disorder: a network pharmacology and molecular docking study revealing phase-specific regulation of longevity and PI3K-Akt pathways

Kai Jiang, Xiangdong Du, Jun Zhang, Hongliang Zhu, Ronghua Li, Tingting Jin, Guangya Zhang, Xuna Yang, Dan Wang

November 29, 2025article en

Abstract

No abstract available for this paper.

BMC PsychiatryVol. 26(1)

Suzhou Guangji Hospital (CN)

Openalex Percentile: Top 56%

Bipolar Disorder and Treatment

DOI Open Access PDF OpenAlex

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