<scp>Cerebrospinal Fluid</scp> Biomarkers of <scp>NLRP3</scp> Pathway, Immune Dysregulation, and Neurodegeneration in Parkinson's Disease: A Meta‐Analysis
The elevation in key downstream and general inflammatory mediators results is consistent with the hypothesized involvement of the NLRP3 inflammasome pathway and neurodegeneration in PD pathogenesis. These results highlight the potential use of CSF inflammatory markers and support further investigation into immunomodulatory strategies for PD. © 2025 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
Authors
- Kathrin Brockmann (ORCID: https://orcid.org/0000-0002-7515-8596)
- Nicoletta Milani Muelhardt
- Gennaro Pagano (ORCID: https://orcid.org/0000-0002-6247-8988)
- Thomas Kustermann (ORCID: https://orcid.org/0000-0003-3263-4174)
- Judith Anzures‐Cabrera
- Éva Mracskó (ORCID: https://orcid.org/0000-0001-6507-4148)
- Venissa Machado (ORCID: https://orcid.org/0000-0001-5214-1014)
- Nima Shariati
- Alina‐Măriuca Marinescu
- Bastian Zinnhardt (ORCID: https://orcid.org/0009-0008-7350-5700)
Institutions
- Roche (Switzerland) (CH)
- German Center for Neurodegenerative Diseases (DE)
- Roche (United Kingdom) (GB)
- Hertie Institute for Clinical Brain Research (DE)
- University of Tübingen (DE)
Publication Details
- Journal
- Movement Disorders
- Published
- 2025-11-29
- DOI
- https://doi.org/10.1002/mds.70103
- Citations
- 2
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.78