Allylation of C(sp <sup>3</sup> )─H Bonds Using a MW/Persulfate Protocol
ABSTRACT The C(sp 3 )─H allylation reaction using allyl phenyl sulfone was affected by persulfate anion (PS) under microwave (MW) irradiation. The MW/PS protocol has been found to be applicable to a wide variety of C(sp 3 )─H bonds of ethers, alkanes, aldehydes, and ketones, leading to the C(sp 3 )─H allylated compounds. The origin of the site‐selectivity in the allylation of cyclohexanone is discussed in terms of the polarity‐governed transition states for the radical cascades involving hydrogen atom transfer (HAT), radical addition, and β‐elimination.
Authors
- Ilhyong Ryu (ORCID: https://orcid.org/0000-0001-7715-4727)
- Yen‐Ku Wu (ORCID: https://orcid.org/0000-0002-9269-7444)
- Hsin‐Hsuan Lee
- Chun‐Yu Chen (ORCID: https://orcid.org/0000-0002-7703-4589)
Institutions
- National Yang Ming Chiao Tung University (TW)
- Osaka Prefecture University (JP)
Publication Details
- Journal
- Helvetica Chimica Acta
- Published
- 2025-11-29
- DOI
- https://doi.org/10.1002/hlca.202500191
- Primary Topic
- Radical Photochemical Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Science and Technology Council
- Japan Society for the Promotion of Science