EFFECTIVENESS OF MEDICAL TREATMENT FOR IDIOPATHİC FREQUENT PREMATURE VENTRICULAR COMPLEXES

Introduction: Premature ventricular complexes (PVCs) are common arrhythmias in the clinical practice with an estimated prevalence of 1 to 4% in the general population. Also catheter ablation is recommended for first line treatment in symptomatic idiopathic ventricular tachycardia but medical treatment is reasanable. The aim of this study is to demonstrate the success rate of combined medical therapy and the factors influencing it in patients presenting with frequent idiopathic premature ventricular complexes. Method: We retrospectively analyzed 60 adult patients who visited the cardiology outpatient clinic between 2022 and 2025. We diagnosed idiopathic PVC via electrocardiography at hospital admission and underwent ambulatory 24-hour rhythm Holter monitoring. Patients were initially divided into two groups based on their response to drug therapy. The demographic data, PVC burden and counts on Holter monitoring, treatment duration, administered medications, and ECG characteristics of PVCs were compared between patients who responded to drug therapy and those who did not. Results: There were two groups; Group 1 was drug-unresponsive group (n=32), Group 2 (n=28) was drug-responsive group. After first treatment period we chanaged and proceed additional medical therapy in drug-unresponsive group. There was significantly positive response to treatment in patients with a transition at V4 in PVCs. We showed that PVC count and burden was significantly higher then in the drug-responsive group, 3 of 32 patients had ablation after first treatment. In the second treatment group (n=29), more than an 80% reduction in PVC burden was observed in 14 of the 29 patients. Overall, 42 out of 60 patients (70%) showed a response to medical therapy. Conclusion: As a result, combination therapy may be given to patients who are not considering interventional treatment for first option or who has not possibility to reach early for ablation.