Identification and validation of SUN modification-related anti-PD-1 immunotherapy-resistance signatures to predict prognosis and immune microenvironment status in glioblastoma
This study established a robust six-gene prognostic model related to SUN modifications and anti-PD-1 therapy in GBM. The model demonstrates strong predictive ability and correlates with clinically relevant parameters, highlighting its potential utility for survival prediction and guiding therapeutic management decisions in GBM patients.
Authors
- Hongxiang Sun (ORCID: https://orcid.org/0000-0003-4849-7127)
- Shuqin Zhan (ORCID: https://orcid.org/0000-0002-2036-4392)
- Meiyan Gao (ORCID: https://orcid.org/0009-0003-7465-439X)
- Huqing Wang
- Hong Zhang (ORCID: https://orcid.org/0000-0001-7670-626X)
- Zhen Gao (ORCID: https://orcid.org/0000-0003-3461-1910)
- Yao Li (ORCID: https://orcid.org/0000-0001-8720-3027)
- Ru Zhang (ORCID: https://orcid.org/0000-0002-4860-7800)
Institutions
- Second Affiliated Hospital of Xi'an Jiaotong University (CN)
- Shaanxi Provincial Hospital of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- BMC Cancer
- Published
- 2025-11-29
- DOI
- https://doi.org/10.1186/s12885-025-15345-9
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00