Development of population pharmacokinetic models of total and free piperacillin in critically ill children and young adults for Monte Carlo simulations and model-informed precision dosing
Using a large sample of critically ill children, we developed total and free piperacillin population PK models and newly identified uNGAL and time as significant covariates on piperacillin clearance. These models may be used for model-informed precision dosing after external validation.
Authors
- Abigayle Gibson
- Erin Stoneman
- Horace Rhodes Hambrick (ORCID: https://orcid.org/0000-0003-1218-8293)
- Patrick Lahni (ORCID: https://orcid.org/0000-0002-3652-0329)
- Peter Torben Tang (ORCID: https://orcid.org/0000-0003-4419-3046)
- Sonya Tang Girdwood (ORCID: https://orcid.org/0000-0001-7737-8499)
- Jennifer Kaplan (ORCID: https://orcid.org/0000-0001-7020-2394)
- Nieko Punt (ORCID: https://orcid.org/0000-0002-7655-6094)
- Ronaldo Morales (ORCID: https://orcid.org/0000-0002-5856-3717)
- Rhonda Jones
- Calise Curry
Institutions
- Northwestern University (US)
- Cincinnati Children's Hospital Medical Center (US)
- University Medical Center Groningen (NL)
- University of Groningen (NL)
- Maastricht University Medical Centre (NL)
- Lurie Children's Hospital (US)
- Northwestern Medicine (US)
- University of Cincinnati Medical Center (US)
Publication Details
- Journal
- Journal of Antimicrobial Chemotherapy
- Published
- 2025-11-05
- DOI
- https://doi.org/10.1093/jac/dkaf423
- Citations
- 1
- Primary Topic
- Antibiotics Pharmacokinetics and Efficacy
- Type
- article
- Field-Weighted Citation Impact
- 1.39