A polygenic risk score for peripheral artery disease and major adverse limb events
In a broad spectrum of patients with cardiometabolic disease, the PAD PRS is associated with an increased risk of PAD and the incidence of MALE beyond clinical risk factors; however, the improvement in discrimination was statistically significant but clinically modest.
Authors
- Deepak L. Bhatt (ORCID: https://orcid.org/0000-0002-1278-6245)
- Christian T. Ruff (ORCID: https://orcid.org/0000-0002-4712-3206)
- Elliott M. Antman (ORCID: https://orcid.org/0000-0002-0808-9199)
- Eugene Braunwald (ORCID: https://orcid.org/0000-0002-3472-626X)
- Frederick Kamanu (ORCID: https://orcid.org/0000-0001-7208-1047)
- Christopher P. Cannon (ORCID: https://orcid.org/0000-0003-4596-2791)
- Marc S. Sabatine (ORCID: https://orcid.org/0000-0002-0691-3359)
- Giorgio Melloni (ORCID: https://orcid.org/0000-0001-6371-1334)
- Robert P. Giugliano (ORCID: https://orcid.org/0000-0003-4110-7675)
- Benjamin M. Scirica (ORCID: https://orcid.org/0000-0002-7093-7048)
- Siddharth M. Patel (ORCID: https://orcid.org/0000-0002-4637-4361)
- Patrick T. Ellinor (ORCID: https://orcid.org/0000-0002-2067-0533)
- Samer Al Said (ORCID: https://orcid.org/0000-0002-3262-3785)
- Michelle L. O’Donoghue (ORCID: https://orcid.org/0000-0002-8663-0067)
- Marc P. Bonaca (ORCID: https://orcid.org/0000-0002-9860-3584)
- Nicholas Marston (ORCID: https://orcid.org/0000-0001-6164-4617)
- Stephen D. Wiviott
Institutions
- Broad Institute (US)
- Brigham and Women's Hospital (US)
- Mount Sinai Hospital (US)
- Thrombolysis in Myocardial Infarction Study Group (US)
- University of Colorado Anschutz Medical Campus (US)
- University of Colorado Denver (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- European Heart Journal
- Published
- 2025-10-22
- DOI
- https://doi.org/10.1093/eurheartj/ehaf891
- Citations
- 2
- Primary Topic
- Peripheral Artery Disease Management
- Type
- article
- Field-Weighted Citation Impact
- 4.01