Opposite aging effects among cell subsets revealed in the human transcriptome and epigenome

In our previous work, we reported a global landscape of opposite aging effects among mouse cell subsets, where each cell subset is defined as a combination of tissue and cell type, and aging leads to increased gene expression in one subset but reduced expression in another. In this study, we investigated whether opposite aging effects are also observed in human cell subsets using the database of differentially expressed genes (DEGs) and differentially accessible regions (DARs) in various human cell subsets. The results suggest that the opposite aging effects occur among human cell subsets at both the transcriptomic and epigenomic levels.