Comparative Effectiveness of Clopidogrel <i>vs</i> . Potent P2Y <sub>12</sub> Inhibitors in <i>CYP2C19</i> Normal Metabolizers Following Percutaneous Coronary Intervention: A Real‐World Cohort Study
Among patients with MI with CYP2C19 NM undergoing percutaneous coronary intervention, the use of potent P2Y₁₂ inhibitors was associated with a reduced risk of thrombotic events at 1 year compared to clopidogrel. These findings indicate genotype-guided de-escalation strategies warrant further investigation across diverse clinical settings.
Authors
- Kuan‐Cheng Chang (ORCID: https://orcid.org/0000-0001-6476-9896)
- Fuu‐Jen Tsai (ORCID: https://orcid.org/0000-0002-1373-245X)
- Edward Chia‐Cheng Lai (ORCID: https://orcid.org/0000-0002-5852-7652)
- Shih‐Sheng Chang (ORCID: https://orcid.org/0000-0002-1664-4818)
- Daniel Hsiang‐Te Tsai (ORCID: https://orcid.org/0000-0003-2841-0338)
- Hsing‐Fang Lu
- Ke‐Wei Chen (ORCID: https://orcid.org/0000-0002-7350-9604)
- Hsing‐Yu Hsu
Institutions
- Asia University (TW)
- National Taiwan University (TW)
- China Medical University (TW)
- China Medical University Hospital (TW)
- RIKEN Center for Integrative Medical Sciences (JP)
- National Cheng Kung University (TW)
- National Yang Ming Chiao Tung University (TW)
Publication Details
- Journal
- British Journal of Clinical Pharmacology
- Published
- 2025-11-29
- DOI
- https://doi.org/10.1002/bcp.70373
- Citations
- 1
- Primary Topic
- Antiplatelet Therapy and Cardiovascular Diseases
- Type
- article
- Field-Weighted Citation Impact
- 1.39
Funders
- China Medical University Hospital