Microtubule Inner Protein CFAP77 Contributes to Sperm Motility and Male Fertility in Mice
We demonstrate that CFAP77 is crucial for sperm motility and male fertility. The interaction between CFAP77 and other microtubule inner proteins suggests a role in stabilizing other microtubule inner proteins and regulating flagellar function. These results provide insights into the molecular mechanisms of sperm motility regulation.
Authors
- Haruhiko Miyata (ORCID: https://orcid.org/0000-0003-4758-5803)
- Mengjiao Luo
- Haoting Wang (ORCID: https://orcid.org/0009-0000-5176-7170)
- Masahito Ikawa (ORCID: https://orcid.org/0000-0001-9859-6217)
- Anh Hoang Pham (ORCID: https://orcid.org/0009-0008-9279-2020)
Institutions
- Osaka Gakuin University (JP)
- Osaka University of Pharmaceutical Sciences (JP)
- The University of Osaka (JP)
Publication Details
- Journal
- Andrology
- Published
- 2025-11-29
- DOI
- https://doi.org/10.1111/andr.70152
- Citations
- 1
- Primary Topic
- Microtubule and mitosis dynamics
- Type
- article
- Field-Weighted Citation Impact
- 1.15
Funders
- Japan Agency for Medical Research and Development
- Ministry of Education, Culture, Sports, Science and Technology
- Japan Society for the Promotion of Science
- Japan Science and Technology Agency
- Research Institute for Microbial Diseases, Osaka University
- National Institute of Child Health and Human Development
- Eunice Kennedy Shriver National Institute of Child Health and Human Development