Extracellular Matrix and Endothelial Activation Markers in the Bronchial and Pulmonary Arteries in COPD
This study demonstrates for the first time ECM remodelling and endothelial activation in bronchial arteries of smokers and patients with COPD. Fibronectin emerges as a key ECM component in arterial remodelling in mild-moderate COPD. Understanding vascular changes may provide new insights into the regulation of bronchial circulation and the development of pulmonary hypertension in COPD.
Authors
- Renata Calciolari Rossi (ORCID: https://orcid.org/0000-0002-3311-064X)
- Pieter S. Hiemstra (ORCID: https://orcid.org/0000-0002-0238-5982)
- Thaís Mauad (ORCID: https://orcid.org/0000-0002-3354-1466)
- Jôse Mára de Brito (ORCID: https://orcid.org/0000-0002-7934-7191)
- Klaus F. Rabe (ORCID: https://orcid.org/0000-0002-7020-1401)
- Raquel Annoni (ORCID: https://orcid.org/0000-0003-2416-7465)
- Salvatore Battaglia (ORCID: https://orcid.org/0000-0002-0421-7480)
- Marisa Dolhnikoff (ORCID: https://orcid.org/0000-0002-9073-9989)
- Ligia Couceiro
- Natália de Souza Xavier Costa (ORCID: https://orcid.org/0000-0002-7848-2092)
- Peter J. Sterk
Institutions
- Universidade Federal de Minas Gerais (BR)
- Universidade de Taubaté (BR)
- Leiden University Medical Center (NL)
- Universidade do Oeste Paulista (BR)
- German Center for Lung Research (DE)
- LungenClinic Grosshansdorf (DE)
- Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (BR)
- Amsterdam University of Applied Sciences (NL)
- University of Amsterdam (NL)
- University of Palermo (IT)
Publication Details
- Journal
- The Clinical Respiratory Journal
- Published
- 2025-11-29
- DOI
- https://doi.org/10.1111/crj.70141
- Primary Topic
- Pulmonary Hypertension Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Conselho Nacional de Desenvolvimento Científico e Tecnológico