Multi-region spatial transcriptomics reveals region specific differences in response to amyloid beta (Aβ) plaque induced changes in Alzheimer’s disease (AD)
Our results demonstrate the value of simultaneously profiling AD-omic and spatial modalities in multiple regions to elucidate how cortical region-specific differences contribute to selective vulnerability and resilience during neurodegeneration. These cortical region and Aβ microenvironment-specific transcriptional changes during AD neurodegeneration highlight the potential for spatially targeted therapeutic approaches.
Authors
- Simon G. Gregory (ORCID: https://orcid.org/0000-0002-7805-1743)
- Odmaa Bayaraa
- Shih‐Hsiu J. Wang (ORCID: https://orcid.org/0000-0002-0358-8159)
- Emily Hocke (ORCID: https://orcid.org/0000-0002-0976-5814)
- Michael Aksu
- Dianne A. Cruz (ORCID: https://orcid.org/0000-0002-5332-6587)
- Evon DeBose-Scarlett (ORCID: https://orcid.org/0000-0002-0488-0717)
- Vaibhav Jain (ORCID: https://orcid.org/0000-0003-0374-8383)
Institutions
- Duke University (US)
Publication Details
- Journal
- Human Genomics
- Published
- 2025-11-29
- DOI
- https://doi.org/10.1186/s40246-025-00875-x
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00