Single-cell transcriptome analysis defines novel molecular subtypes and reveals therapeutic implications of T/myeloid mixed-phenotype acute leukemia
Our study provides new insights into the molecular heterogeneity and offers personalized diagnostic and therapeutic targets for T/My MPAL patients. These findings offer valuable insights for enhancing patient outcomes and developing personalized treatment strategies.
Authors
- Qianghu Wang (ORCID: https://orcid.org/0000-0002-3488-1059)
- Lingxiang Wu (ORCID: https://orcid.org/0000-0003-4319-7862)
- Yuxin Du (ORCID: https://orcid.org/0000-0001-7429-3238)
- Shiyang Zhong (ORCID: https://orcid.org/0000-0001-8568-6467)
- Xianglin Hu (ORCID: https://orcid.org/0000-0002-7133-9867)
- Ruohan Zhang (ORCID: https://orcid.org/0000-0002-7099-7067)
- Ming Hong (ORCID: https://orcid.org/0000-0003-3989-8543)
- Wanting Zhou (ORCID: https://orcid.org/0000-0003-0867-4117)
- Renhong Huang (ORCID: https://orcid.org/0000-0001-9342-2031)
- Kening Li (ORCID: https://orcid.org/0000-0002-3340-0292)
- Chuanyang Lu (ORCID: https://orcid.org/0000-0001-7640-5774)
- Jinning Shi
- Yu Liang (ORCID: https://orcid.org/0000-0003-4259-6028)
- Bin Huang (ORCID: https://orcid.org/0000-0001-6295-6647)
- Sali Lv
- Wenjie Liu (ORCID: https://orcid.org/0000-0002-4907-2465)
- Ping Liu (ORCID: https://orcid.org/0000-0003-1895-338X)
- Xian Zhang (ORCID: https://orcid.org/0000-0002-2691-5247)
- Wei Wu (ORCID: https://orcid.org/0000-0002-6228-0605)
- Liwei Zhu (ORCID: https://orcid.org/0000-0002-7436-3707)
- Qian Sun (ORCID: https://orcid.org/0000-0002-0297-5376)
- Zhi Wang (ORCID: https://orcid.org/0000-0003-2408-9882)
- Sixuan Qian (ORCID: https://orcid.org/0000-0003-1049-4238)
- Peng Xia (ORCID: https://orcid.org/0009-0007-8137-4555)
- Xia Lin (ORCID: https://orcid.org/0009-0008-6125-0341)
- Zixing Lu
- Yuzhu Shi
- Chunling Wang
Institutions
- Xuzhou Medical College (CN)
- Wuhan University (CN)
- Zhongnan Hospital of Wuhan University (CN)
- Second People’s Hospital of Huai’an (CN)
- Wuxi No.2 People's Hospital (CN)
- Jiangsu Cancer Hospital (CN)
- Jiangsu Province Hospital (CN)
- Nanjing Jiangning Hospital (CN)
- Wuxi People's Hospital (CN)
- Southeast University (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Genome Medicine
- Published
- 2025-11-29
- DOI
- https://doi.org/10.1186/s13073-025-01585-8
- Primary Topic
- Acute Myeloid Leukemia Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00