Effect on Dyskinesia of the Early Combination of Amantadine to Levodopa‐Therapy in Parkinson's Disease: A Randomized, Placebo‐Controlled Study ( <scp>PREMANDYSK</scp> )
Adjunctive amantadine-IR in early PD halved dyskinesia incidence over 18 months. Long-lasting mechanisms could not be demonstrated and merit further investigation. Exploratory positive findings on the potential benefit of amantadine-IR on symptoms like freezing of gait and fatigue also call for further investigation. © 2025 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
Authors
- Nicolas Carrière (ORCID: https://orcid.org/0000-0003-3900-5557)
- Jean‐Christophe Corvol (ORCID: https://orcid.org/0000-0001-7325-0199)
- Umberto Spampinato (ORCID: https://orcid.org/0000-0002-0497-8693)
- M Giroud
- David J. Burn (ORCID: https://orcid.org/0000-0001-7658-1209)
- Eugénie Mutez (ORCID: https://orcid.org/0000-0002-5947-0432)
- Joaquim José Ferreira (ORCID: https://orcid.org/0000-0003-3950-5113)
- Ana Marquès (ORCID: https://orcid.org/0000-0003-2428-4899)
- Stéphane Prange (ORCID: https://orcid.org/0000-0002-0812-7634)
- Christian Gény (ORCID: https://orcid.org/0000-0002-8870-9529)
- Romain Lefaucheur (ORCID: https://orcid.org/0000-0002-9592-5940)
- Stéphane Thobois (ORCID: https://orcid.org/0000-0002-9639-6702)
- Claire Thalamas (ORCID: https://orcid.org/0000-0003-1893-519X)
- Monique Galitzky
- Olivier Rascol (ORCID: https://orcid.org/0000-0002-1410-6397)
- Hélène Catalá
- Guillaume Costentin (ORCID: https://orcid.org/0000-0002-4184-0570)
- Alexandra Samier‐Foubert
- Vanessa Rousseau (ORCID: https://orcid.org/0000-0001-7518-7891)
- Mahmoud Charif (ORCID: https://orcid.org/0000-0002-3111-9069)
- Agnès Sommet (ORCID: https://orcid.org/0000-0001-7980-5650)
- Fabienne Ory‐Magne (ORCID: https://orcid.org/0000-0001-6179-4500)
- Isabelle Bénatru (ORCID: https://orcid.org/0000-0002-3642-6914)
- Louise‐Laure Mariani (ORCID: https://orcid.org/0000-0002-2365-1223)
- Margherita Fabbri (ORCID: https://orcid.org/0000-0001-7250-592X)
- Jean‐Philippe Azulay (ORCID: https://orcid.org/0000-0001-6624-3329)
- Philippe Damier (ORCID: https://orcid.org/0000-0003-3869-0564)
- David Maltête (ORCID: https://orcid.org/0000-0002-5246-3379)
- Mathieu Anheim (ORCID: https://orcid.org/0000-0001-8121-0605)
- Wassilios G. Meissner (ORCID: https://orcid.org/0000-0003-2172-7527)
- Christine Brefel‐Courbon (ORCID: https://orcid.org/0009-0002-7262-2338)
- Amandine Saubion
- Jean‐Luc Houéto (ORCID: https://orcid.org/0000-0002-6029-8289)
- Luc Defebvre
- François Viallet
- Alexandre Eusébio (ORCID: https://orcid.org/0000-0003-4923-0248)
Institutions
- Université Claude Bernard Lyon 1 (FR)
- Centre National de la Recherche Scientifique (FR)
- University of Lisbon (PT)
- Université de Bordeaux (FR)
- Inserm (FR)
- Université Fédérale de Toulouse Midi-Pyrénées (FR)
- Aix-Marseille Université (FR)
- Université de Lille (FR)
- Université de Poitiers (FR)
- Sorbonne Université (FR)
- Institut des Maladies Neurodégénératives (FR)
- Centre de Recherche en Neurosciences de Lyon (FR)
- New Zealand Brain Research Institute (NZ)
- University of Clermont Auvergne (FR)
- Hôpital Pierre Wertheimer (FR)
- Centre Hospitalier Intercommunal Aix-Pertuis (FR)
- Centre Hospitalier Universitaire de Limoges (FR)
- Centre d'Investigation Clinique de Nantes (FR)
- Centre Hospitalier Universitaire de Clermont-Ferrand (FR)
- Institut de Psychiatrie et Neurosciences de Paris (FR)
- Société du Canal de Provence (FR)
- Maison des Sciences sociales et des Humanités de Dijon (FR)
- Services déconcentrés d'appui à la recherche Occitanie-Montpellier (FR)
- French Clinical Research Infrastructure Network (FR)
- Université de Rouen Normandie (FR)
- Université de Limoges (FR)
- Université de Strasbourg (FR)
- University of Otago (NZ)
- Newcastle University (GB)
- Nantes Université (FR)
Publication Details
- Journal
- Movement Disorders
- Published
- 2025-11-29
- DOI
- https://doi.org/10.1002/mds.70120
- Citations
- 1
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.39
Funders
- Ministère de la Santé
- Université de Toulouse