Association of Epigenetic Aging Biomarkers With Risk of <scp>MASLD</scp> ‐Related <scp>HCC</scp>
Higher relative age accelerations of PCPhenoAge, PCGrimAge and DunedinPACE aging rate are associated with risk of MASLD-HCC. These aging biomarkers could improve HCC risk assessment and facilitate risk stratification in patients with MASLD.
Authors
- Kirk J. Wangensteen (ORCID: https://orcid.org/0000-0001-6042-6490)
- Laura Izquierdo‐Sánchez (ORCID: https://orcid.org/0000-0002-7016-8314)
- Amit G. Singal (ORCID: https://orcid.org/0000-0002-1172-3971)
- Samuel O. Antwi (ORCID: https://orcid.org/0000-0003-2372-9489)
- Fowsiyo Ahmed (ORCID: https://orcid.org/0000-0002-0201-6706)
- Ángela Rojas (ORCID: https://orcid.org/0000-0003-0853-4800)
- Anders Berglund (ORCID: https://orcid.org/0000-0002-0393-3530)
- Per Stål (ORCID: https://orcid.org/0000-0003-2915-1964)
- Manuel Romero‐Gómez (ORCID: https://orcid.org/0000-0001-8494-8947)
- Lewis R. Roberts (ORCID: https://orcid.org/0000-0001-7885-8574)
- Loreto Boix (ORCID: https://orcid.org/0000-0002-6015-3901)
- Tushar Patel (ORCID: https://orcid.org/0000-0002-7823-2579)
- Sebastian M. Armasu (ORCID: https://orcid.org/0000-0002-9796-7087)
- Irene K. Yan (ORCID: https://orcid.org/0000-0003-0593-5027)
- María Reig (ORCID: https://orcid.org/0000-0002-5711-9534)
- Jesús M. Bañales (ORCID: https://orcid.org/0000-0002-5224-2373)
- Alani Perkin
- Winnie Z. Fan (ORCID: https://orcid.org/0009-0000-7193-4132)
- Naana N. Yalley (ORCID: https://orcid.org/0009-0001-8245-9231)
Institutions
- Ikerbasque (ES)
- Mayo Clinic (US)
- Karolinska University Hospital (SE)
- University of the Basque Country (ES)
- Jacksonville College (US)
- WinnMed (US)
- Karolinska Institutet (SE)
- Biogipuzkoa Health Research Institute (ES)
- Centre for Biomedical Network Research on Rare Diseases (ES)
- Hospital Clínic de Barcelona (ES)
- Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (ES)
- Instituto de Biomedicina de Sevilla (ES)
- Mayo Clinic in Florida (US)
- Consorci Institut D'Investigacions Biomediques August Pi I Sunyer (ES)
- Universitat de Barcelona (ES)
- The University of Texas Southwestern Medical Center (US)
- Universidad de Navarra (ES)
Publication Details
- Journal
- Liver International
- Published
- 2025-11-29
- DOI
- https://doi.org/10.1111/liv.70464
- Citations
- 2
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 2.71