Postmalnutrition weight gain is associated with changes to muscle and energy metabolism in adolescence: a cohort analysis
Individuals with greater PMWG exhibited lower muscle-related metabolites and altered energy metabolism in adolescence. It remains unclear whether this reflects inherent differences in how individuals gain weight, or whether early-life weight gain programs future metabolic states. Elucidating these mechanisms will inform interventions to ameliorate long-term health risks, an urgent priority following the growing double burden of malnutrition in low- and middle-income countries.
Authors
- Marko Kerac (ORCID: https://orcid.org/0000-0002-3745-7317)
- Jonathan R. Swann (ORCID: https://orcid.org/0000-0002-6485-4529)
- Natasha Lelijveld (ORCID: https://orcid.org/0000-0002-8452-0198)
- Amir Kirolos (ORCID: https://orcid.org/0000-0003-2995-330X)
- Colleen S. Deane (ORCID: https://orcid.org/0000-0002-2281-6479)
- Thandile Nkosi-Gondwe (ORCID: https://orcid.org/0000-0003-0999-1114)
- Amelia Catharine Crampin (ORCID: https://orcid.org/0000-0002-1513-4330)
- Elizabeth Wimborne
- Grace O’Donovan (ORCID: https://orcid.org/0009-0000-1926-3634)
Institutions
- University of London (GB)
- University of Liverpool (GB)
- London School of Hygiene & Tropical Medicine (GB)
- Ministry of Health (MW)
- Malawi Epidemiology and Intervention Research Unit (MW)
- University of Southampton (GB)
Publication Details
- Journal
- American Journal of Clinical Nutrition
- Published
- 2025-11-29
- DOI
- https://doi.org/10.1016/j.ajcnut.2025.101130
- Primary Topic
- Child Nutrition and Water Access
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Wellcome Trust
- Medical Research Council