Amelogenin Peptide Promotes Human Dental Pulp Cell Proliferation and Odontogenic Differentiation via ERK1/2 Pathway
The amelogenin peptide stimulates both the proliferation and odontogenic differentiation of HDPCs via the ERK1/2 pathway. These findings suggest that the amelogenin peptide may have significant implications for regenerative dentistry, particularly in the context of dentine-pulp complex regeneration.
Authors
- Guanhua Wang (ORCID: https://orcid.org/0000-0001-9334-8740)
- Shihui Jiang
- Huiru Zou (ORCID: https://orcid.org/0000-0001-7931-5264)
- Xiaoban Li
- Zhaoxia Yu (ORCID: https://orcid.org/0000-0002-8443-6789)
- Xiaoli Lian (ORCID: https://orcid.org/0000-0003-4473-747X)
- Zhimou Yang (ORCID: https://orcid.org/0000-0003-2967-6920)
- Xiaohua Dai (ORCID: https://orcid.org/0000-0002-2891-159X)
- Xinxin Li (ORCID: https://orcid.org/0009-0005-3188-1503)
- Yue Wang (ORCID: https://orcid.org/0000-0002-2719-287X)
- Yan Yan (ORCID: https://orcid.org/0000-0001-5325-6737)
Institutions
- Ministry of Education (KR)
- Tianjin Stomatological Hospital (CN)
- Kementerian Pendidikan Malaysia (MY)
Publication Details
- Journal
- International Dental Journal
- Published
- 2025-11-29
- DOI
- https://doi.org/10.1016/j.identj.2025.109304
- Citations
- 1
- Primary Topic
- Periodontal Regeneration and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.84