Fahr’s syndrome: Evaluation of bilateral basal ganglia and calcifications in other brain regions: A report of 3 cases

Fahr's syndrome is a rare neurological disorder characterized by abnormal intracranial calcifications, most commonly affecting the basal ganglia. We report 3 cases-2 females aged 71 and 72, and 1 male aged 47-who were incidentally found to have bilateral basal ganglia calcifications on brain CT-scans. The first patient had a history of total thyroidectomy and parathyroidectomy; the second had prior psychiatric illness and was evaluated after a motor vehicle accident; the third was undergoing chemotherapy for hepatocellular carcinoma and presented with generalized weakness. Stroke was excluded in all cases, and each patient was discharged in stable condition. These cases highlight the importance of neuroimaging in identifying Fahr's syndrome, especially in atypical presentations, and underscore the need for thorough metabolic and clinical evaluation to guide diagnosis and management.

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Journal
Radiology Case Reports
Published
2025-11-29
DOI
https://doi.org/10.1016/j.radcr.2025.10.090
Primary Topic
Thyroid and Parathyroid Surgery
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article
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article

Fahr’s syndrome: Evaluation of bilateral basal ganglia and calcifications in other brain regions: A report of 3 cases

Soheil Mirzaei, Reza Naseri, Zahra Motaghed, Farzin Lotfi et al.
Radiology Case Reports
Thyroid and Parathyroid Surgery
article

Fahr’s syndrome: Evaluation of bilateral basal ganglia and calcifications in other brain regions: A report of 3 cases

Soheil Mirzaei, Reza Naseri, Zahra Motaghed, Farzin Lotfi, Sara Arab Baferani
article en

Abstract

Fahr's syndrome is a rare neurological disorder characterized by abnormal intracranial calcifications, most commonly affecting the basal ganglia. We report 3 cases-2 females aged 71 and 72, and 1 male aged 47-who were incidentally found to have bilateral basal ganglia calcifications on brain CT-scans. The first patient had a history of total thyroidectomy and parathyroidectomy; the second had prior psychiatric illness and was evaluated after a motor vehicle accident; the third was undergoing chemotherapy for hepatocellular carcinoma and presented with generalized weakness. Stroke was excluded in all cases, and each patient was discharged in stable condition. These cases highlight the importance of neuroimaging in identifying Fahr's syndrome, especially in atypical presentations, and underscore the need for thorough metabolic and clinical evaluation to guide diagnosis and management.

Radiology Case ReportsVol. 21(2)
Tarbiat Modares University (IR), Shahid Beheshti University of Medical Sciences (IR)
Openalex Percentile: Top 43%
Thyroid and Parathyroid Surgery
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Fahr’s syndrome: Evaluation of bilateral basal ganglia and calcifications in other brain regions: A report of 3 cases — Soheil Mirzaei, Reza Naseri, et al. · Radiology Case Reports (2025) | TGRS Research Map | TGRS