The Glutamine Metabolic Switch Influences the Response of Neonatal Intestinal Macrophages to Breast Milk
Glutamine and glutamate exert dual, context-dependent effects in neonatal enteritis by modulating macrophage glutamine metabolism. These findings provide mechanistic insight and suggest a basis for personalized glutamine supplementation strategies in neonatal gut disorders.
Authors
- Yahui Zhou (ORCID: https://orcid.org/0000-0001-5445-4292)
- Zhenyu Jia
- Weilai Jin
- Yafei Su (ORCID: https://orcid.org/0000-0001-6412-6559)
- Xu Han (ORCID: https://orcid.org/0000-0002-9317-774X)
- Yutong Hou (ORCID: https://orcid.org/0000-0002-3569-2284)
- Fuqiang Yuan
- Ru Yan
- Le Zhang (ORCID: https://orcid.org/0000-0003-4787-0524)
- Xiaolei Wang (ORCID: https://orcid.org/0000-0003-3403-1174)
- Yun Li (ORCID: https://orcid.org/0000-0001-6276-9104)
- Mingxin Wang (ORCID: https://orcid.org/0000-0001-9587-3434)
- Tuo Chen (ORCID: https://orcid.org/0000-0003-2441-9829)
Institutions
- Jiangnan University (CN)
- Shanghai Jiao Tong University (CN)
- Soochow University (CN)
- Wuxi Fourth People's Hospital (CN)
- Jiangxi Provincial Children's Hospital (CN)
- First Affiliated Hospital of Soochow University (CN)
- Wuxi People's Hospital (CN)
Publication Details
- Journal
- Cellular and Molecular Gastroenterology and Hepatology
- Published
- 2025-11-29
- DOI
- https://doi.org/10.1016/j.jcmgh.2025.101683
- Citations
- 1
- Primary Topic
- Clinical Nutrition and Gastroenterology
- Type
- article
- Field-Weighted Citation Impact
- 1.12