Common and distinct roles of AMPKγ isoforms in small-molecule activator-stimulated glucose uptake in mouse skeletal muscle
While γ1 predominates in stabilizing the AMPKα2β2γ1 complex, it is dispensable for AMPK activator-stimulated glucose uptake in skeletal muscle, whether mediated via the nucleotide-binding or ADaM site.
Authors
- Marianne Agerholm (ORCID: https://orcid.org/0000-0001-8687-1031)
- Danial Ahwazi (ORCID: https://orcid.org/0000-0003-2747-2684)
- Amy M. Ehrlich (ORCID: https://orcid.org/0000-0003-4830-1024)
- Agnete N Schou
- Jonas T. Treebak (ORCID: https://orcid.org/0000-0003-1488-7012)
- Marc Foretz (ORCID: https://orcid.org/0000-0001-7017-9032)
- Jordana B. Freemantle (ORCID: https://orcid.org/0009-0005-0968-1986)
- Charline Jomard
- Dipsikha Biswas (ORCID: https://orcid.org/0000-0003-0990-9678)
- Julien Gondin (ORCID: https://orcid.org/0000-0002-3108-605X)
- Jean Farup (ORCID: https://orcid.org/0000-0002-7579-6512)
- Jesper Just (ORCID: https://orcid.org/0000-0002-3825-0000)
- Ever Espino‐Gonzalez (ORCID: https://orcid.org/0000-0001-5371-227X)
- Kei Sakamoto (ORCID: https://orcid.org/0000-0001-6894-6175)
- Jonas Brorson
Institutions
- Université Claude Bernard Lyon 1 (FR)
- University of Copenhagen (DK)
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Université Paris Cité (FR)
- Novo Nordisk Foundation (DK)
- Aarhus University Hospital (DK)
- Institut NeuroMyoGène (FR)
- Institut Cochin (FR)
Publication Details
- Journal
- Molecular Metabolism
- Published
- 2025-11-29
- DOI
- https://doi.org/10.1016/j.molmet.2025.102294
- Primary Topic
- Metabolism, Diabetes, and Cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Novo Nordisk
- Novo Nordisk Foundation Center for Basic Metabolic Research
- Centro de Investigação em Biomedicina