From Gene to Enzyme: Multidimensional Decoding of the <scp>GGT</scp> Molecular Family and Its Clinical Tumor Diagnosis
The GGT molecular family plays pleiotropic roles in tumor biology via redox homeostasis, EMT, and immune modulation. The GGT1/5/7 and GGT-II isoforms represent promising biomarkers for early diagnosis, prognosis, and therapeutic targeting in multiple cancers. Future multicenter studies should validate GGT-based biomarker panels and elucidate the mechanisms underlying tissue-specific GGT functions.
Authors
- Xiaomin Lu (ORCID: https://orcid.org/0009-0008-5617-4225)
- Xuebing Xu (ORCID: https://orcid.org/0009-0006-0979-6473)
- Xudong Xie (ORCID: https://orcid.org/0000-0002-5932-1496)
- J. Yang (ORCID: https://orcid.org/0000-0002-3974-8636)
- Mingbing Xiao (ORCID: https://orcid.org/0000-0003-3372-1069)
- Xiaogang Hu (ORCID: https://orcid.org/0000-0002-8565-5940)
- Xinlin He (ORCID: https://orcid.org/0000-0002-4771-5682)
- Feng Zhu (ORCID: https://orcid.org/0000-0001-6030-9251)
- Yuxuan Huang (ORCID: https://orcid.org/0009-0001-4639-1604)
- Fei Wang (ORCID: https://orcid.org/0000-0002-5670-1944)
- Junpeng Zhao
- Lirong Zhou
Institutions
- Nantong University (CN)
- Affiliated Hospital of Nantong University (CN)
- JiangSu Armed Police General Hospital (CN)
- Second People's Hospital of NanTong (CN)
- Anyang Hospital of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Cancer Medicine
- Published
- 2025-11-28
- DOI
- https://doi.org/10.1002/cam4.71165
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Government of Jiangsu Province
- Natural Science Foundation of Jiangsu Province