Mortality Benefit of Tranexamic Acid for Hemorrhage With Concurrent Traumatic Brain Injury: Outcomes From a Prospective Cohort Study in a High‐Trauma, Prolonged Care Setting
In this study, the administration of TXA within 3 h to patients with concurrent hemorrhage and TBI was associated with a 22% reduction in mortality at 7 days. The mortality benefit was slightly larger when TXA was given within 2 h. TXA treatment was also associated with lower risk of organ failure. These results support a growing body of evidence that TXA is an effective intervention to reduce mortality and morbidity after traumatic injury.
Authors
- Hendrick J. Lategan
- Dale A. Barnhart (ORCID: https://orcid.org/0000-0003-0129-0313)
- Elaine Erasmus (ORCID: https://orcid.org/0000-0002-5136-8468)
- Julia Dixon (ORCID: https://orcid.org/0000-0002-9229-2658)
- Janette Verster (ORCID: https://orcid.org/0000-0002-1273-5456)
- Craig Wylie (ORCID: https://orcid.org/0000-0003-2168-4838)
- Nee‐Kofi Mould‐Millman (ORCID: https://orcid.org/0000-0003-4303-6903)
- Steven Gremel Schauer (ORCID: https://orcid.org/0000-0002-2322-5216)
- Adane F. Wogu (ORCID: https://orcid.org/0000-0002-6592-6512)
- Shaheem de Vries (ORCID: https://orcid.org/0000-0003-3986-1652)
- María de los Ángeles Rodríguez Gázquez (ORCID: https://orcid.org/0000-0002-4329-4286)
- Rachel Patel (ORCID: https://orcid.org/0000-0003-4592-0815)
- George Oosthuizen
Institutions
- Western Cape Department of Health (ZA)
- Colorado School of Public Health (US)
- Stellenbosch University (ZA)
- Government of South Africa (ZA)
- United States Army Institute of Surgical Research (US)
- Right to Care (ZA)
- University of Colorado Anschutz Medical Campus (US)
Publication Details
- Journal
- World Journal of Surgery
- Published
- 2025-11-28
- DOI
- https://doi.org/10.1002/wjs.70161
- Primary Topic
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Department of Health, Western Cape Government
- Defense Health Agency