Microgravity activates monocyte ERK1/2 signaling and modulates the response to lipopolysaccharide
Microgravity redistributes monocyte signaling states, increasing basal ERK1/2 activity while attenuating rapid stimulus-induced activation and expanding the non-responsive cell fraction. These findings provide new mechanistic insight into how microgravity shapes immune signaling and highlight cellular heterogenety as a critical determinant of immune regulation during spaceflight.
Authors
- Auke P. Verhaar (ORCID: https://orcid.org/0000-0002-3853-6113)
- Ruslan A. Mammadov (ORCID: https://orcid.org/0000-0002-7311-213X)
- Maikel Petrus Peppelenbosch (ORCID: https://orcid.org/0000-0001-9112-6028)
- Marilyn Bakker (ORCID: https://orcid.org/0009-0006-1328-4753)
- Maj Hultén (ORCID: https://orcid.org/0009-0000-4178-8330)
Institutions
- Erasmus MC (NL)
- Erasmus University Rotterdam (NL)
Publication Details
- Journal
- Molecular Medicine
- Published
- 2025-11-29
- DOI
- https://doi.org/10.1186/s10020-025-01407-y
- Primary Topic
- Spaceflight effects on biology
- Type
- article
- Field-Weighted Citation Impact
- 0.00