The Epidemiology of Primary Lateral Sclerosis: Results from a Population‐Based Cohort
PLS was confirmed to be rarer than other ALS phenotypes. Patients had a higher age at onset than previously reported and a female predominance. Sex, age at onset, and respiratory function were key prognostic factors. ANN NEUROL 2026;99:606-613.
Authors
- Antonio Canosa (ORCID: https://orcid.org/0000-0001-5876-4079)
- Gabriele Mora (ORCID: https://orcid.org/0000-0002-8388-2373)
- Salvatore Gallone (ORCID: https://orcid.org/0000-0002-3156-4613)
- Elisa D’Angelo (ORCID: https://orcid.org/0000-0002-5954-0939)
- Enrico Matteoni (ORCID: https://orcid.org/0009-0008-2963-8821)
- Andrea Calvo (ORCID: https://orcid.org/0000-0002-5122-7243)
- Umberto Manera (ORCID: https://orcid.org/0000-0002-9995-8133)
- Fabrizio D’Ovidio (ORCID: https://orcid.org/0000-0001-6304-5415)
- Sara Cabras (ORCID: https://orcid.org/0000-0002-4988-2855)
- Rosario Vasta (ORCID: https://orcid.org/0000-0002-0393-4736)
- Fabiola De Marchi (ORCID: https://orcid.org/0000-0003-0197-1880)
- Alessandra Maccabeo (ORCID: https://orcid.org/0009-0005-7779-5897)
- Francesca Palumbo (ORCID: https://orcid.org/0000-0002-7070-2409)
- Giorgio Pellegrino
- Cristina Moglia (ORCID: https://orcid.org/0000-0001-7377-7222)
- Adriano Chiò (ORCID: https://orcid.org/0000-0001-9579-5341)
- Maurizio Grassano
Institutions
- Università di Camerino (IT)
- Università degli Studi del Piemonte Orientale “Amedeo Avogadro” (IT)
- Azienda Ospedaliera Citta' della Salute e della Scienza di Torino (IT)
- Zero to Three (US)
- Azienda Ospedaliero Universitaria Maggiore della Carita (IT)
- National Research Council (IT)
- Institute of Cognitive Sciences and Technologies (IT)
- University of Turin (IT)
Publication Details
- Journal
- Annals of Neurology
- Published
- 2025-11-28
- DOI
- https://doi.org/10.1002/ana.78105
- Primary Topic
- Amyotrophic Lateral Sclerosis Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00