Integrating serum pharmacochemistry with network pharmacology and pharmacological validation to elucidate the mechanism of KaiXinSan in treating insomnia
KXS treats insomnia by regulating serotonin synapse signaling pathways and inflammatory responses, and influencing arachidonic acid and tryptophan metabolism.
Authors
- Junbo Zou (ORCID: https://orcid.org/0000-0002-1651-4722)
- Jiangxue Cheng (ORCID: https://orcid.org/0009-0007-3229-0478)
- Dongyan Guo (ORCID: https://orcid.org/0000-0001-6863-805X)
- Chongbo Zhao
- Huanxian Shi (ORCID: https://orcid.org/0000-0002-3792-7913)
- Xiaofei Zhang (ORCID: https://orcid.org/0000-0002-4837-0188)
- Shihao Zhang (ORCID: https://orcid.org/0000-0002-5781-2080)
- Jing Sun (ORCID: https://orcid.org/0000-0002-5390-5327)
- Yajun Shi (ORCID: https://orcid.org/0000-0002-3682-7099)
Institutions
- Shaanxi University of Chinese Medicine (CN)
Publication Details
- Journal
- BMC Complementary Medicine and Therapies
- Published
- 2025-11-29
- DOI
- https://doi.org/10.1186/s12906-025-05196-z
- Primary Topic
- Sleep and related disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00