Recent Advances in Spirocyclization Reactions of Biaryl Ynones

In recent years, special emphasis has been put on spirocyclization reactions of biaryl ynones since these strategies offer versatile platforms for introducing various important functional groups into spirocyclic frameworks in a step‐economical manner, which is conducive to drug discovery. In this regard, various functionalized spiro[5.5]trienones and 3,3‐spiroindanones have been synthesized via the radical, radical cation, or electrophilic process promoted by thermal, photochemical, and electrochemical means. In this invited review, we systematically summarize the spirocyclization reactions of biaryl ynones with diverse organic precursors, highlighting the reaction patterns, mechanistic insights, and synthetic applications.