Identification of Key Biomarkers for Systemic Lupus Erythematosus Progression and Therapy Response: A Bulk RNA‐Sequencing‐Based Bioinformatics Study
This study demonstrates that SLC4A1, GATA1, DMTN, and SNCA are potential biomarkers for diagnosing SLE and monitoring therapeutic efficacy. The integrated diagnostic approach exhibited robust predictive power, and N-acetyl-L-cysteine was identified as a viable therapeutic agent. These findings provide valuable insights for enhancing the early diagnosis and development of targeted therapies for SLE.
Authors
- Jian Shi (ORCID: https://orcid.org/0000-0002-0481-3442)
- Han Li (ORCID: https://orcid.org/0000-0002-9299-0026)
- Lixue Huang (ORCID: https://orcid.org/0000-0002-9110-9436)
- Qing Lin (ORCID: https://orcid.org/0000-0003-0039-6394)
Institutions
- Guangxi University of Science and Technology (CN)
- Liuzhou General Hospital (CN)
- The First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine (CN)
- First Affiliated Hospital of GuangXi Medical University (CN)
- Second People’s Hospital of Yibin (CN)
Publication Details
- Journal
- Brain and Behavior
- Published
- 2025-11-28
- DOI
- https://doi.org/10.1002/brb3.71098
- Primary Topic
- Systemic Lupus Erythematosus Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00