Dosimetric Feasibility of Dose-Painting Radiation Therapy for Targeting Hypoxia in Prostate Cancer on a Novel Ring Gantry Radiation Therapy System
This study demonstrated the dosimetric feasibility of dose escalation in both the tumor and hypoxic regions in patients with prostate cancer using the RefleXion treatment planning system, without compromising the dose limits for organs at risks.
Authors
- Dorine de Jong (ORCID: https://orcid.org/0000-0003-4366-9145)
- Stéphane Supiot
- M Alexandra
- O.M. Oderinde (ORCID: https://orcid.org/0000-0001-8120-1821)
- Karine A. Al Feghali (ORCID: https://orcid.org/0000-0002-5538-1336)
- Ludovic Ferrer (ORCID: https://orcid.org/0000-0002-5166-1998)
- Grant Gibbard
- Caroline Rousseau (ORCID: https://orcid.org/0000-0002-0455-0523)
- Tanguy Perennec (ORCID: https://orcid.org/0000-0002-1118-2271)
- G. Delpon (ORCID: https://orcid.org/0000-0002-7023-2259)
- Yves Seroux
- Matthieu Hatt
- Mélanie Dore
Institutions
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Université de Bretagne Occidentale (FR)
- Purdue University West Lafayette (US)
- Centre de Recherche en Cancérologie et Immunologie Intégrée Nantes Angers (FR)
- RefleXion Medical (United States) (US)
- Institut de Cancérologie de l'Ouest (FR)
- Laboratoire de Thermique et Energie de Nantes (FR)
- Laboratoire des Sciences du Numérique de Nantes (FR)
- Laboratoire de Traitement de l'Information Médicale (FR)
- Unité en Sciences Biologiques et Biotechnologies de Nantes (FR)
Publication Details
- Journal
- Advances in Radiation Oncology
- Published
- 2025-11-29
- DOI
- https://doi.org/10.1016/j.adro.2025.101940
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- RefleXion Medical