Impact of disease-modifying therapy on [99mTc]Tc-DPD SPECT/CT markers in transthyretin cardiac amyloidosis enabled by artificial intelligence
AI-driven [<sup>99m</sup>Tc]Tc-DPD SPECT/CT analysis effectively detects treatment-induced reductions in cardiac amyloid burden, offering a non-invasive biomarker for early response assessment in ATTR-CM. AI-enabled imaging markers enhance reproducibility and efficiency, providing valuable support for personalized treatment strategies as new therapeutic options for ATTR-CM become available.
Authors
- Christian Hengstenberg (ORCID: https://orcid.org/0000-0002-8284-2994)
- Michaela Auer‐Grumbach (ORCID: https://orcid.org/0000-0001-6609-8918)
- Clemens P. Spielvogel (ORCID: https://orcid.org/0000-0002-4409-8324)
- Jing Ning (ORCID: https://orcid.org/0000-0002-5289-331X)
- Josef Yu (ORCID: https://orcid.org/0000-0003-1426-1538)
- Raffaella Calabretta (ORCID: https://orcid.org/0000-0002-8018-3884)
- Nikita Ermolaev (ORCID: https://orcid.org/0000-0003-4317-9277)
- Roza Badr Eslam (ORCID: https://orcid.org/0000-0002-0360-2360)
- David Kersting (ORCID: https://orcid.org/0000-0002-8451-1830)
- Johannes Kästner (ORCID: https://orcid.org/0000-0001-6178-7669)
- Franz Duca (ORCID: https://orcid.org/0000-0002-7519-5274)
- Markus Köfler (ORCID: https://orcid.org/0000-0002-2962-0903)
- Christina Binder (ORCID: https://orcid.org/0000-0001-6060-7910)
- Michael Poledniczek (ORCID: https://orcid.org/0000-0002-6091-9823)
- Jutta K Bergler-Klein (ORCID: https://orcid.org/0000-0003-2591-1380)
- Christina Kronberger (ORCID: https://orcid.org/0000-0002-3866-3710)
- René Rettl (ORCID: https://orcid.org/0000-0001-6409-5158)
- Andreas Anselm Kammerlander (ORCID: https://orcid.org/0000-0002-7632-9879)
- Zewen Jiang (ORCID: https://orcid.org/0009-0005-0172-868X)
- David Haberl
- Christian Nitsche
- Marcus Hacker (ORCID: https://orcid.org/0000-0002-4222-4083)
- Lena Marie Schmid
Institutions
- Austrian Research Institute for Artificial Intelligence (AT)
- Essen University Hospital (DE)
- University of Duisburg-Essen (DE)
- Medical University of Vienna (AT)
Publication Details
- Journal
- European Journal of Nuclear Medicine and Molecular Imaging
- Published
- 2025-11-29
- DOI
- https://doi.org/10.1007/s00259-025-07673-6
- Citations
- 1
- Primary Topic
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- Universität Wien
- Medizinische Universität Wien