The Epidemiology, Phylogeny, and Strain Antigenicity of an Influenza A/H3N2 Virus Outbreak Among Vaccinated US Navy Midshipmen
We performed epidemiological, genetic, and antigenic characterization of an influenza A/H3N2 outbreak in a congregate setting of young adults with high vaccination rates. We noted substantial duty-days lost, rapid spread, and vaccine antigenic divergence. The risk of influenza in healthy vaccinated adults underscores the need to develop universal influenza vaccines.
Authors
- Kat Schmidt (ORCID: https://orcid.org/0000-0002-1240-6767)
- Timothy H. Burgess (ORCID: https://orcid.org/0000-0003-1247-8370)
- Stephanie A Richard (ORCID: https://orcid.org/0000-0002-0530-384X)
- Anthony C Fries (ORCID: https://orcid.org/0000-0001-7556-1353)
- Drake H. Tilley
- Simon Pollett (ORCID: https://orcid.org/0000-0002-4450-7028)
- Mark P. Simons (ORCID: https://orcid.org/0000-0002-4316-9709)
- Rhonda E Colombo (ORCID: https://orcid.org/0000-0003-0154-1928)
- Emily Hone
- M. Wayman
- Appavu K. Sundaram (ORCID: https://orcid.org/0009-0001-4964-470X)
- Jennifer Rothenberg
- Robert J. O’Connell
- Vivian Hogan
- Daniel Ewing (ORCID: https://orcid.org/0000-0001-7910-6526)
Institutions
- Henry M. Jackson Foundation (US)
- Naval Medical Research Command (US)
- Uniformed Services University of the Health Sciences (US)
- United States Naval Academy (US)
- Wright-Patterson Air Force Base (US)
Publication Details
- Journal
- Influenza and Other Respiratory Viruses
- Published
- 2025-11-28
- DOI
- https://doi.org/10.1111/irv.70184
- Primary Topic
- Influenza Virus Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of Defense
- Henry M. Jackson Foundation
- Uniformed Services University of the Health Sciences
- Defense Health Agency