Six-Minute Activity-95th Centile, a Novel Wearable-Derived Clinical Outcome Assessment for Duchenne Muscular Dystrophy
Ambulatory and nonambulatory patients with Duchenne muscular dystrophy were differentiated by 6-min activity and declined over time, modeling progression of skeletal myopathy. Six-minute activity-95<sup>th</sup> centile has potential for future use as an effort-independent outcome of skeletal muscle progression and functional decline for both ambulatory and nonambulatory individuals.
Authors
- Christopher F. Spurney (ORCID: https://orcid.org/0000-0003-2493-5735)
- W. Bryan Burnette (ORCID: https://orcid.org/0000-0002-7637-5330)
- Brian D. Soriano (ORCID: https://orcid.org/0000-0002-7959-1960)
- Jennifer S. Li (ORCID: https://orcid.org/0000-0002-3254-1712)
- Carol Wittlieb‐Weber (ORCID: https://orcid.org/0000-0002-1299-3201)
- Katheryn Gambetta (ORCID: https://orcid.org/0000-0002-1796-9171)
- Rakesh Pilkar (ORCID: https://orcid.org/0000-0002-3433-9913)
- Nazia Husain (ORCID: https://orcid.org/0000-0003-4743-2313)
- Jaclyn G. Tamaroff (ORCID: https://orcid.org/0000-0002-3630-9937)
- Kimberly Crum (ORCID: https://orcid.org/0000-0003-2112-1541)
- Frank J. Raucci (ORCID: https://orcid.org/0000-0002-3464-6569)
- James C. Slaughter (ORCID: https://orcid.org/0000-0002-8770-980X)
- Jonathan H. Soslow (ORCID: https://orcid.org/0000-0001-9194-5330)
- Jay A. Campbell
- Larry W. Markham (ORCID: https://orcid.org/0000-0002-2804-4641)
- Beth D. Kaufman (ORCID: https://orcid.org/0000-0003-0484-5281)
- Kan N. Hor (ORCID: https://orcid.org/0000-0003-4628-5227)
- Christine C. Guo (ORCID: https://orcid.org/0000-0003-1530-0172)
- Andrew Liu (ORCID: https://orcid.org/0000-0001-5522-1263)
- Nicholas Joy (ORCID: https://orcid.org/0009-0005-1400-797X)
- Weiqing Wang (ORCID: https://orcid.org/0000-0002-9578-819X)
- Xu Meng (ORCID: https://orcid.org/0000-0001-7438-5933)
- Jonathan Dayan (ORCID: https://orcid.org/0000-0002-5906-5605)
- Karry Su
Institutions
- Northwestern University (US)
- Lurie Children's Hospital (US)
- Children's National (US)
- Seattle Children's Hospital (US)
- Pensacola Historical Society (US)
- Children's Hospital of Richmond at VCU (US)
- Indiana University School of Medicine
- The Ohio State University (US)
- Indiana University – Purdue University Indianapolis (US)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- Pediatric Neurology
- Published
- 2025-11-29
- DOI
- https://doi.org/10.1016/j.pediatrneurol.2025.11.017
- Primary Topic
- Muscle Physiology and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- American Heart Association
- National Heart, Lung, and Blood Institute
- National Institute of Diabetes and Digestive and Kidney Diseases