Elucidation of Cortex Dictamni hepatotoxicity mechanism by integrated serum pharmacochemistry and metabolomics
This study is the first to analyze the components of DIC using serum medicinal chemistry to identify the main toxicants and to elucidate the potential molecular mechanism of DIC-induced hepatotoxicity. The results of this study provide an important theoretical basis for further investigations of the mechanism of DIC toxicity and the development of toxicity reduction strategies. These results are also important for promoting the safe use of DIC and the modernization of traditional Chinese medicine.
Authors
- Sujie Liu
- Shumin Liu (ORCID: https://orcid.org/0000-0002-7267-7542)
- Donghua Yu (ORCID: https://orcid.org/0000-0002-4295-9565)
- Jianbin Ruan (ORCID: https://orcid.org/0000-0001-5843-8273)
- Chen Wang (ORCID: https://orcid.org/0000-0001-7985-0881)
- Na Zhang (ORCID: https://orcid.org/0000-0002-5706-641X)
- Yu Wang (ORCID: https://orcid.org/0000-0003-1753-0289)
- Xiaoyun Wang (ORCID: https://orcid.org/0000-0002-3489-7579)
- Pingping Chen (ORCID: https://orcid.org/0000-0002-8027-4620)
- Fang Lü (ORCID: https://orcid.org/0000-0003-1247-1523)
- Jie Yan (ORCID: https://orcid.org/0000-0003-2939-5395)
Institutions
- Heilongjiang University of Chinese Medicine (CN)
Publication Details
- Journal
- Phytomedicine
- Published
- 2025-11-29
- DOI
- https://doi.org/10.1016/j.phymed.2025.157631
- Citations
- 1
- Primary Topic
- Drug-Induced Hepatotoxicity and Protection
- Type
- article
- Field-Weighted Citation Impact
- 1.56