Acute and chronic effects of imeglimin on peripheral circadian clocks in mice
In this study, we demonstrated that imeglimin alters peripheral clock gene expression in healthy mice under both acute bolus administration and chronic mixed-feeding conditions. Further studies are warranted to clarify underlying mechanisms and their physiological relevance.
Authors
- Yifan Shi (ORCID: https://orcid.org/0000-0002-1164-2469)
- Hiroshi Fujiwara (ORCID: https://orcid.org/0000-0003-3098-9406)
- Ryo Miyazaki (ORCID: https://orcid.org/0000-0002-1996-709X)
- Tomohiro Iba (ORCID: https://orcid.org/0009-0001-4311-5380)
- Hitoshi Ando (ORCID: https://orcid.org/0000-0001-6179-9993)
- Tomoko Fujiwara (ORCID: https://orcid.org/0000-0002-3329-0361)
- Jun‐ichi Morishige
- Naoki Sakane (ORCID: https://orcid.org/0000-0002-2625-571X)
- Masanori Ono (ORCID: https://orcid.org/0000-0001-9249-6813)
- Naoto Nagata (ORCID: https://orcid.org/0000-0002-2389-2334)
- Pingping Xu (ORCID: https://orcid.org/0000-0002-3040-5098)
- Yunze Yang (ORCID: https://orcid.org/0000-0003-4776-4588)
- Takashi Hosono
Institutions
- Kanazawa University (JP)
- Tokyo Medical University (JP)
- Kanazawa Medical University (JP)
- Shimane University (JP)
- Kyoto Medical Center (JP)
- Kyoto Notre Dame University (JP)
Publication Details
- Journal
- Journal of Pharmacological Sciences
- Published
- 2025-11-29
- DOI
- https://doi.org/10.1016/j.jphs.2025.11.005
- Primary Topic
- Circadian rhythm and melatonin
- Type
- article
- Field-Weighted Citation Impact
- 0.00