Photocatalyst‐Free Photochemical Trifluoromethylation/Cyclization of Unactivated Alkenes: Synthesis of Trifluoromethyl‐Substituted Quinazolinones
A novel photochemical trifluoromethylation/cyclization of unactivated alkenes to synthesize trifluoromethyl‐substituted quinazolinones with trifluoromethylsulfonyl‐pyridinium salt (TFSP) is achieved under catalyst‐free conditions. Mechanistic studies reveal that an electron‐donating‐accepting complex is formed between the quinazolinone and TFSP, making this the first example of TFSP‐based trifluoromethylation conducted in the absence of expensive iridium photocatalysts.
Authors
- Z. Y. Zhang (ORCID: https://orcid.org/0009-0004-9282-4425)
- Kui Lu (ORCID: https://orcid.org/0000-0002-9685-2691)
- Guohua Jin (ORCID: https://orcid.org/0000-0001-7853-2574)
- Xia Zhao (ORCID: https://orcid.org/0000-0001-9477-5912)
- Yu Zhao (ORCID: https://orcid.org/0000-0003-0115-9489)
- Qianqian Feng (ORCID: https://orcid.org/0000-0003-4565-5951)
Institutions
- Tianjin University of Science and Technology (CN)
- Tianjin Normal University (CN)
Publication Details
- Journal
- Advanced Synthesis & Catalysis
- Published
- 2025-11-28
- DOI
- https://doi.org/10.1002/adsc.70144
- Primary Topic
- Fluorine in Organic Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 0.00