Androgen Signaling in ILC2s Drives Sex Differences in Helicobacter-induced Gastric Inflammation and Atrophy
This study reveals that androgens protect from Helicobacter-induced gastric inflammation by modulating ILC2 activation. These findings indicate that ILC2s serve as master regulators of Helicobacter-driven gastric inflammation and highlight their role in directing sex differences in the progression of pre-dysplastic disease.
Authors
- Jordan L. Pascoe
- Stuti Khadka (ORCID: https://orcid.org/0000-0001-5794-0587)
- Jonathan T. Busada (ORCID: https://orcid.org/0000-0001-5886-9858)
- Gangqing Hu (ORCID: https://orcid.org/0000-0001-5453-6888)
- Benjamin C. Duncan (ORCID: https://orcid.org/0000-0001-5943-2631)
- Lei Wang (ORCID: https://orcid.org/0000-0001-6604-3175)
- Maeve T. Morris (ORCID: https://orcid.org/0000-0003-1439-6731)
Institutions
- West Virginia University (US)
- West Virginia University Hospitals (US)
Publication Details
- Journal
- Cellular and Molecular Gastroenterology and Hepatology
- Published
- 2025-11-29
- DOI
- https://doi.org/10.1016/j.jcmgh.2025.101690
- Primary Topic
- IL-33, ST2, and ILC Pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.00