Curcumin induces ferroptosis in hepatocellular carcinoma by regulating the P62-KEAP1-NRF2-signaling pathway
Our findings demonstrate that curcumin suppresses the P62-KEAP1-NRF2-signaling pathway to induce ferroptosis, a key mechanism underlying its anti-tumor effects. This study not only provides a novel scientific basis for the application of curcumin but also reveals potential therapeutic targets for hepatocellular carcinoma.
Authors
- Yangli Yu (ORCID: https://orcid.org/0000-0002-5326-1904)
- Shangkun Ning (ORCID: https://orcid.org/0000-0002-6614-6315)
- Jinlan Deng (ORCID: https://orcid.org/0000-0002-7925-0429)
- Zhijuan Wu (ORCID: https://orcid.org/0000-0001-5878-108X)
- Chang Xu (ORCID: https://orcid.org/0000-0003-2737-4312)
- Lin Zhang (ORCID: https://orcid.org/0000-0003-0018-3903)
- Min Zhang (ORCID: https://orcid.org/0000-0001-7055-6790)
- Jibing Liu
Institutions
- Shandong University of Traditional Chinese Medicine (CN)
- Jinan Central Hospital (CN)
- Affiliated Zhongshan Hospital of Dalian University (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- BMC Cancer
- Published
- 2025-11-29
- DOI
- https://doi.org/10.1186/s12885-025-15307-1
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00