Sodium oligomannate modulates the gut-brain axis to alleviate post-stroke cognitive impairment by restoring butyrate metabolism
Intestinal butyrate levels are significantly associated with PSCI. GV-971 mitigates post-stroke cognitive decline by modulating the gut microbiota to increase butyrate production, highlighting its potential as a therapeutic agent for PSCI.
Authors
- Qiheng Wu (ORCID: https://orcid.org/0000-0001-6448-7688)
- Jiahui Xie
- Yueran Ren (ORCID: https://orcid.org/0009-0008-8121-3142)
- Yifeng Zheng (ORCID: https://orcid.org/0000-0003-2292-5314)
- Jia Yin (ORCID: https://orcid.org/0000-0001-8944-6604)
- Jiafeng Zhang (ORCID: https://orcid.org/0000-0003-0650-9556)
- Jingru Liang (ORCID: https://orcid.org/0000-0002-2423-0666)
- Xiao Li (ORCID: https://orcid.org/0009-0005-4703-1714)
- Weike Hu
- Minlin Lai
- Hongwei Zhou (ORCID: https://orcid.org/0009-0006-1229-0705)
Institutions
- Nanfang Hospital (CN)
- Zhujiang Hospital (CN)
- Southern Medical University Shenzhen Hospital (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- Microbiome
- Published
- 2025-11-29
- DOI
- https://doi.org/10.1186/s40168-025-02257-w
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00