Lysine restriction attenuates obesity-related anxiety-like behaviors via increasing Oscillibacter ruminantium-mediated tryptophol regulation
LRD attenuates obesity-associated anxiety-like behaviors by enriching Oscillibacter ruminantium and modulating tryptophol production, thereby activating the FTO-IGF2BP1-LGR6 signaling axis. These findings would indicate LRD as a microbiota-directed therapeutic strategy for neurobehavioral comorbidities of metabolic stress.
Authors
- Ruiqi Zhou (ORCID: https://orcid.org/0009-0005-9470-773X)
- Feng Zhao (ORCID: https://orcid.org/0000-0002-8309-0536)
- Jingfu Qiu (ORCID: https://orcid.org/0000-0003-1220-7319)
- Xinhao Duan
- Chengzhi Chen (ORCID: https://orcid.org/0000-0002-1087-4911)
- Hongyang Zhang (ORCID: https://orcid.org/0000-0001-5643-8237)
- Jiao Wang (ORCID: https://orcid.org/0000-0003-0981-6033)
- Yuehua Wu
- Liang Wang (ORCID: https://orcid.org/0000-0003-2244-7535)
- Zhaoyi Liu (ORCID: https://orcid.org/0000-0002-5583-5473)
- Fanwei Sun
- Huaili Feng
- Congyan Wang (ORCID: https://orcid.org/0000-0002-0734-5461)
- Ahmad Khan
- Ting You
Institutions
- Chinese University of Hong Kong (HK)
- Hong Kong Jockey Club (HK)
- Chongqing Public Health Medical Center (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Microbiome
- Published
- 2025-11-29
- DOI
- https://doi.org/10.1186/s40168-025-02217-4
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00