Cyclopropyl‐enhanced bioavailability, not target‐site potency, drives the herbicidal activity of <scp>FM</scp> ‐1688, a novel <scp>PPO</scp> inhibitor
The cyclopropyl-containing pyrimidinedione derivative FM-1688 represents a highly promising herbicide candidate. Its superior in vivo activity appears to be driven by cyclopropyl-enhanced pharmacokinetic properties (bioavailability) rather than enhanced target-site binding. This finding provides a new rationale for agrochemical design, warranting further development for sustainable weed management. © 2025 Society of Chemical Industry.
Authors
- Yixing Gao (ORCID: https://orcid.org/0009-0008-2832-8426)
- Jialin Ye
- Dongdong Liu (ORCID: https://orcid.org/0000-0002-3749-6527)
- Jing Zhang (ORCID: https://orcid.org/0000-0002-7560-121X)
- Lixin Zhang (ORCID: https://orcid.org/0000-0003-0423-0818)
- H. Pei (ORCID: https://orcid.org/0009-0001-6541-9131)
Institutions
- University of Science and Technology Liaoning (CN)
- Shenyang University of Technology (CN)
- Health First (US)
- Nanning Normal University (CN)
- Shenyang University of Chemical Technology (CN)
Publication Details
- Journal
- Pest Management Science
- Published
- 2025-11-28
- DOI
- https://doi.org/10.1002/ps.70412
- Primary Topic
- Weed Control and Herbicide Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00