Defective autophagy and AMPK inactivation drive ferroptosis in diabetic kidney disease
These findings demonstrate that impaired autophagy and inactivated AMPK heighten susceptibility to ferroptosis in DKD, suggesting that therapeutic strategies targeting autophagy and AMPK activation may reduce ferroptosis-associated kidney injury in individuals with diabetes.
Authors
- Yoshitsugu Takabatake (ORCID: https://orcid.org/0000-0002-8912-2316)
- Yoshitaka Isaka (ORCID: https://orcid.org/0000-0002-0820-7167)
- Isao Matsui (ORCID: https://orcid.org/0000-0001-8378-6130)
- Sho Matsui (ORCID: https://orcid.org/0000-0002-1146-5079)
- Jun Matsuda (ORCID: https://orcid.org/0000-0003-1492-6157)
- Hiroaki Yonishi (ORCID: https://orcid.org/0000-0002-0529-9350)
- Motoko Yanagita (ORCID: https://orcid.org/0000-0002-0339-9008)
- Satoshi Minami (ORCID: https://orcid.org/0000-0001-5043-3435)
- Tomoko Namba‐Hamano (ORCID: https://orcid.org/0000-0002-6049-7616)
- Jun Nakamura (ORCID: https://orcid.org/0000-0002-9345-3740)
- Takeshi Yamamoto (ORCID: https://orcid.org/0009-0007-3817-0557)
- Hideaki Kawai
- Shinsuke Sakai
- Atsushi Takahashi (ORCID: https://orcid.org/0009-0004-2698-7920)
- Takuya Kubota
Institutions
- Osaka University of Economics (JP)
- Kyoto University (JP)
- Osaka University of Pharmaceutical Sciences (JP)
Publication Details
- Journal
- Diabetologia
- Published
- 2025-11-28
- DOI
- https://doi.org/10.1007/s00125-025-06612-2
- Citations
- 2
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 3.04
Funders
- Eli Lilly and Company
- Boehringer Ingelheim Japan
- Osaka Kidney Bank
- Ministry of Education, Culture, Sports, Science and Technology
- Ichiro Kanehara Foundation for the Promotion of Medical Sciences and Medical Care
- Kanae Foundation for the Promotion of Medical Science
- Japan Diabetes Foundation
- Eli Lilly Japan
- Japan Society for the Promotion of Science