Research progress on ferroptosis in drug resistance and therapy of gastric cancer
Targeting ferroptosis presents a promising and innovative research avenue for reversing drug resistance in gastric cancer. Strategies designed to induce ferroptosis effectively overcome common resistance mechanisms and hold significant therapeutic potential. Future research must focus on integrating multi-omics technologies and advanced drug delivery systems to decipher the complex regulatory networks of ferroptosis within the TME and to develop biomarkers for personalized treatment, thereby paving the way for improved clinical outcomes.
Authors
- Lizhou Jia (ORCID: https://orcid.org/0000-0003-0645-1868)
- Yuexin Liu (ORCID: https://orcid.org/0000-0002-0828-4656)
- Yang Liu (ORCID: https://orcid.org/0000-0002-9284-1944)
- Yanmei Li (ORCID: https://orcid.org/0000-0003-2116-1607)
- Ning Zhang (ORCID: https://orcid.org/0000-0002-1559-111X)
Institutions
- Second Affiliated Hospital of Inner Mongolia Medical University (CN)
- Inner Mongolia Autonomous Region Hospital of Traditional Chinese Medicine (CN)
- Inner Mongolia Medical University (CN)
Publication Details
- Journal
- Journal of Cancer Research and Clinical Oncology
- Published
- 2025-11-28
- DOI
- https://doi.org/10.1007/s00432-025-06372-x
- Citations
- 2
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 3.04
Funders
- Natural Science Foundation of Inner Mongolia